Landau-Kleffner syndrome: Relation of clinical, EEG and Tc-99m-HMPAO brainSPECT findings and improvement in EEG after treatment

Landau-Kleffner syndrome (LKS) is a rare childhood disorder characterized b y acquired aphasia with seizures and electroencephalogram (EEG) abnormaliti es. Tc-99m-HMPAO SPECT was performed in three right handed children with LK S. A relative decrease in perfusion was found in the left temporal cortex o f all three patients and also in the left frontoparietal cortex of one pati ent with hyperkinetic behavior. Degree of regional cerebral perfusion impai rment did not correlate with the severity of clinical and EEG abnormalities . Asymmetrical temporoparietal perfusion appears characteristic of LKS. SPE CT findings in LKS were evaluated as useful in elucidating the pathogenic f eatures of the disorder in the brain.