Estimation of volume referent bone turnover in the otic capsule after sequential point labeling

Using fluorochrome labeling and a newly validated method for bone turnover estimation, we determined absolute values for canine perilabyrinthine bone remodeling. The overall capsular bone turnover was found to be 2.1% per yea r, compared to 13.9% per year for the neighboring cranial bones and 7.4% pe r year for the humerus compacta. This gross 2.1% per year conceals a vast r ange, from 0.13% per year for the innermost perilymphatic zone, through a c entrifugal increment toward 8% to 10% per year in the periphery. The underl ying individual bone remodeling units exhibit a similar centrifugal pattern in numerical density and size. These findings indicate an inhibition of re modeling, seemingly emanating from the perilymphatic spaces, and affecting both the activation of osteoclasts and the extent of resorption by the oste oclasts. These values satisfactorily explain the preservation of such fetal remnants as the globuli ossei, the interglobular spaces, and the skein bon e. In humans, local ineffective inhibition of bone resorption may play a ro le in the initiation of otosclerosis.