We present 4 cases of schwannomas arising from the cervical sympathetic cha
in. These lesions are uncommon and most often present as an asymptomatic so
litary neck mass. Preoperative diagnosis can be difficult, even with the ai
d of computed tomography, magnetic resonance imaging, ultrasound, and angio
graphy. While a paraganglioma con often be ruled out, exact determination o
f the nerve of origin is frequently elusive until the time of surgery. Oper
ative excision remains the treatment of choice. often requiring sacrifice o
f a portion of the sympathetic chain. Postoperative Horner's syndrome is co
mmon, bur does not appear to have an adverse effect on the patient.