Preventive effect of hesperidin against inflammation in CD-1 mouse skin caused by tumor promoter

Ow earlier studies have shown thar the flavonoid hesperidin inhibits tumor promotion in a two stage skin tumorigenesis protocol in CD-l mice. In this study hesperidin's significant protection (p<0.0001) against 12-0-tetradeca noylphorbol-13-acetate (TPA) induced edema in CD-I mouse ear will be presen ted. Hesperidin also afforded significant protection against TPA induced hy perplasia in the dorsal skin through multiple application prior to TPA. Pro tection by hesperidin was 93% of the epidermal thickness and 100% of the ve rtical cell layers The data also indicate the protective effect of hesperid in against TPA caused infiltration of neutrophils by 73%. These results sug gest that hesperidin may possess potential as chemopreventive agent against tumor promoter induced inflammation and hyperplasia.