Treatment of alloimmune neonatal neutropenia with granulocyte colony-stimulating factor (G-CSF): a report of two new cases

Alloimmune neonatal neutropenia is a rare event. Usually asymptomatic, if m ay however in some cases result in a severe sepsis. Treatment with recombin ant granulocyte colony-stimulating factor (G-CSF) has been recently propose d Case reports. - We report two new cases in infected newborns of a success ful treatment of alloimmune neonatal neutropenia with G-CSF, resulting in c omplete neutrophil recovery in less than 72 hours. Moreover, the treatment was well tolerated Conclusion. - The analysis of these two cases and of tho se previously reported indicates that G-CSF represents the first-choice tre atment in this affection when infectious signs are present in the neonate. (C) 1999 Editions scientifiques et medicales Elsevier SAS.