Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series

Authors
Bonnet, B Soullez, D Girault, S Maes, L Landry, V Davioud-Charvet, E Sergheraert, C
Citation
B. Bonnet et al., Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series, BIO MED CH, 8(1), 2000, pp. 95-103
Citations number
27
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
8
Issue
1
Year of publication
2000
Pages
95 - 103
Database
ISI
SICI code
0968-0896(200001)8:1<95:TRIARI>2.0.ZU;2-U
Abstract
A series of symmetrically substituted 1,4-bis(3-aminopropyl)piperazines was synthesized and tested towards trypanothione reductase and for its in vitr o trypanocidal potency. The most trypanocidal amongst them was found to be totally inactive towards the enzyme and thus constitutes a lead structure f or the identification of new potential Trypanosoma cruzi target(s). (C) 200 0 Elsevier Science Ltd. All rights reserved.