Synthesis, spectroscopic characterization and biological properties of newnatural aldehydes thiosemicarbazones

As part of a research programme aimed at the synthesis of compounds with an tiviral antibacterial and antitumor properties and their spectroscopic char acterization, new thiosemicarbazones deriving from natural aldehydes have b een investigated. These substances contain in the same molecule both a chai n with nucleophilic centres N, S with tubercolostatic activity, and a glyco sidic or alkyl moiety (modified glycosides and nucleosides have recently re ceived a great deal of attention in the fields of neoplastic diseases and v iral infections). In this paper the synthesis and the characterization of t hese compounds by means of H-1 NMR, IR, and MS techniques is reported. Biol ogical studies have involved both inhibition of cell proliferation and apop tosis rests on human leukemia cell line U937, (C) 2000 Elsevier Science Ltd . All rights reserved.