Production of the antibiotic gallidermin by Staphylococcus gallinarum - development of a scale-up procedure

A scale-up strategy into 200 l pilot-scale for the production of the antibi otic gallidermin by Staphylococcus gallinarum Tu 3928 was developed. Large- scale fermentations were simulated by consecutive liquid cultures of smalle r scale. Afterwards, optimised cultivation conditions were transferred to p ilot-scale. Best results were achieved by addition of Maltose during the la te production phase leading to a final concentration of 330 mg gallidermin per litre. Compared to the concentrations found in a non-pulsed pilot-scale fermentations this is an increase of 20-30%.