For cosmetic applications, papain or lysozyme was conjugated to a soluble b
iopolymer produced by Schizophyllum commune. Stability of the conjugated en
zymes were significantly enhanced, such that more than 90% of the initial a
ctivity remained after a month storage at 45 degrees C, even in a cosmetic
formulation including various oils and surfactants. Cosmetic lotion contain
ing 1% papain conjugate was more effective in exfoliating stratum corneum o
f skin than the lotion containing 5% lactic acid, one of the popular exfoli
ating agents.