Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance

Authors
Lage, H Helmbach, H Dietel, M Schadendorf, D
Citation
H. Lage et al., Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance, BR J CANC, 82(2), 2000, pp. 488-491
Citations number
18
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
82
Issue
2
Year of publication
2000
Pages
488 - 491
Database
ISI
SICI code
0007-0920(200001)82:2<488:MODTIA>2.0.ZU;2-E
Abstract
The role of DNA topoisomerases (Topo) II alpha and II beta was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etop oside, exhibited an up to tenfold reduced Topo II activity corresponding to an increasing degree of drug resistance indicating that modulation of Topo II activity contribute to the drug-resistant phenotype. The reduction of T opo II activity was reflected by decreased nuclear amounts of both Topo II isoforms. (C) 2000 Cancer Research Campaign.