S. Nakamura et al., A clinicopathologic study of primary small intestine lymphoma - Prognosticsignificance of mucosa-associated lymphoid tissue-derived lymphoma, CANCER, 88(2), 2000, pp. 286-294
BACKGROUND. It remains unclear whether the presence of mucosa-associated ly
mphoid tissue (MALT) lymphoma has prognostic implications for patients with
primary small intestine lymphoma.
METHODS. The clinicopathologic features of 80 patients with primary small i
ntestine lymphoma were examined retrospectively in relation to the presence
of MALT lymphoma. Survival was compared univariately and multivariately am
ong the groups divided by clinicopathologic findings.
RESULTS. Twenty-one cases (26%) were diagnosed as low grade E-cell lymphoma
(15 marginal zone B-cell lymphoma of MALT type, 2 mantle cell lymphoma, an
d 4 follicle center lymphoma), 46 cases (58%) were diagnosed as high grade
B-cell lymphoma (19 secondary large cell lymphoma with a low grade MALT com
ponent, 17 diffuse large cell lymphoma without MALT features, 7 Burkitt lym
phoma, and 3 lymphoblastic lymphoma), and 13 cases (16%) were diagnosed as
T-cell lymphoma. a significantly better survival was noted for patients wit
hout colorectal and/or gastric involvement, diffuse infiltration under manr
oscopy, high grade histology, and perforation. Those patients with MALT typ
e tumors, less advanced stage of disease, B-cell phenotype, benign lymphoid
; follicular hyperplasia, and radical tumor resectability appeared to have
a better survival rate. Based on Cox multivariate analysis, early stage dis
ease-and MALT-derived tumors were determined to he independent prognostic f
actors (P < 0.05).
CONCLUSIONS. The presence of MALT-derived lymphoma appears to have a favora
ble prognosis among patients with primary small intestinal lymphoma, (C) 20
00 American Cancer Society.