Ws. Park et al., A distinct tumor suppressor gene locus on chromosome 15q21.1 in sporadic form of colorectal cancer, CANCER RES, 60(1), 2000, pp. 70-73
The SM1311 family is an Ashkenazi family with dominantly inherited predispo
sition to colorectal adenomas and carcinomas and has a high-penetrance locu
s in chromosome 15q, with a multipoint logarithm of the odds score of 3.06
at marker D15S118. In the present study, we performed a high-density loss o
f heterozygosity study with 13 polymorphic microsatellite markers, includin
g D15S118, spanning 15q15.3-q22.1, on 70 cases of the sporadic form of colo
rectal tumors. Our deletion mapping data showed a locus at D15S968 in chrom
osomal sub-band 15q21.1 may harbor a tumor suppressor gene in an area <0.52
1 Mb in physical map distance defined by markers D15S514 and D15S222. THBS1
, 0.185 Mb proximal to D15S968, is the nearest known gene to this specific
narrow loss of heterozygosity region. Thus, we speculate that THBS1 might b
e the most probable candidate gene involved in colorectal cancer carcinogen
esis.