Lipid A and related compounds. XXXVII. Determination of favorable binding linkages of lipid A analog to antigen moiety for synthetic vaccines

Authors
Ikeda, K Miyajima, K Shimizu, T Achiwa, K
Citation
K. Ikeda et al., Lipid A and related compounds. XXXVII. Determination of favorable binding linkages of lipid A analog to antigen moiety for synthetic vaccines, CHEM PHARM, 48(1), 2000, pp. 32-40
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
1
Year of publication
2000
Pages
32 - 40
Database
ISI
SICI code
0009-2363(200001)48:1<32:LAARCX>2.0.ZU;2-M
Abstract
For the determination of favorable binding linkages of lipid A analog as a synthetic immanoadjuvant to the antigen moiety for synthetic vaccines, new N-acylated L-serine-containing D-glucosamine analogs (Type A, B, C) were sy nthesized and their mitogenicities were examined, Among chemically synthesi zed compounds (6-15, 30), compound 8 for Type B exhibited the most potent m itogenicity.