2-hydroxy-5-(ethanolamino)-3-(10 '-Z-pentadecenyl)-1,4-benzoquinone, new microbial phase II metabolite of maesanin

Authors
Abourashed, EA El-Feraly, FS Khan, IA Hufford, CD
Citation
Ea. Abourashed et al., 2-hydroxy-5-(ethanolamino)-3-(10 '-Z-pentadecenyl)-1,4-benzoquinone, new microbial phase II metabolite of maesanin, CHEM PHARM, 48(1), 2000, pp. 45-47
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
1
Year of publication
2000
Pages
45 - 47
Database
ISI
SICI code
0009-2363(200001)48:1<45:2'NM>2.0.ZU;2-U
Abstract
The use of microbial models for biotransformation of the natural benzoquino ne, maesanin (1), resulted in the isolation of an ethanolamine conjugate (5 ) from the culture broth of Debaryomyces polymorphus ATCC 20288, Metabolite 5 was characterized as 2-hydroxy-5-(ethanolamino)-3-(10'-Z-pentadecenyl)-1 ,4-benzoquinone. The production of 5 represents a new type of phase II conj ugation reaction in microbial systems. The results of preliminary mammalian metabolism of 1 in rats were inconclusive.