The influence of water molecules in the structure-activity relationship study of sulfonylurea molecules

Authors
Ma, Y Liu, J Li, ZM
Citation
Y. Ma et al., The influence of water molecules in the structure-activity relationship study of sulfonylurea molecules, CHEM J CH U, 21(1), 2000, pp. 85-87
Citations number
5
Categorie Soggetti
Chemistry
Journal title
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN journal
02510790 → ACNP
Volume
21
Issue
1
Year of publication
2000
Pages
85 - 87
Database
ISI
SICI code
0251-0790(200001)21:1<85:TIOWMI>2.0.ZU;2-P
Abstract
A study of some sulfonylurea molecules with consideration of water molecule s as its solvent was undertaken, The influence of the water molecules on th e structure-activity relationship of the 35 sulfonylurea molecules was disc ussed. By supper-imposition of structural sulfonyl molecules, a molecular R MS was correlated with PI50, which denotes that the configuration differenc e in water solution is one of the reasons which causes the difference in bi oactivity.