C. Iribarren et al., Cigarette smoking, alcohol consumption, and risk of ARDS - A 15-year cohort study in a managed cave setting, CHEST, 117(1), 2000, pp. 163-168
Citations number
41
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Study objective: To examine the association of cigarette smoking and alcoho
l consumption with hospital presentation of ARDS in a wed-defined, multieth
nic population.
Design: Retrospective cohort study.
Setting: Health maintenance organization in Northern California,
Participants: A total of 121,012 health plan subscribers (54.2% women), age
d 25 to 89 years.
Outcome measure: Hospital presentation of ARDS (validated by medical chart
review) from baseline in 1979 to 1985 through the end of 1993 (median, 9.9
years).
Results: There were 56 cases of ARDS (33 in men, 23 in women). The case fat
ality rate was 39% in both genders. ARDS was independently, related to incr
easing age (rate ratio of 10 years, 1.38; 95% confidence internal [CI], 1.1
2 to 1.71), to current smoking of < 20 cigarettes/d (rate ratio vs never ci
garette smokers, 2.85; 95% CI, 1.23 to 6,60), and to current cigarette smok
ing of greater than or equal to 20 cigarettes/d (rate ratio vs never smoker
s, 4.59; 95% CI, 2,13 to 9,88), No association was observed between alcohol
consumption and ARDS.
Conclusions: The results of this study suggest a relationship (with evidenc
e of dose-response effect) between cigarette smoking and ARDS, Assuming a c
ausal relationship, approximately 50% of ARDS cases were attributable to ci
garette smoking.