A case of cigarette smoking induced acute eosinophilic pneumonia showing tolerance

It has been proposed that acute eosinophilic pneumonia (AEP), which is char acterized by the absence of recurrence, is associated with cigarette smokin g (CS), because Japanese patients with AEP are young and have a high incide nce of short-term smoking history. However, there has been no direct eviden ce that CS causes AEP. We hypothesized that tolerance might develop against repeated resumption of smoking cigarettes in CS-induced AEP cases. In this connection, we challenged a patient with CS-induced AEP with repeated resu mption of CS, and it was demonstrated that CS induced AEP in conjunction wi th tolerance to repeated resumption of smoking.