Synthesis, characterization and antitumor activities of Co, Ni, Cu, Zn complexes with 1,4,7-10-tetrakis (4-nitrobenzyl)-1, 4,7,10-tetraazacyclododecane macrocyclic ligand

New tetraazamacrocyclic ligand with 1, 4, 7, 10-tetrakis (4-nitrobenzyl) pe ndent groups (C36H40N8O8, M-r = 712. 76) crystallized in the monoclinic sys tem, P2(1)/n space group with unit cell parameters: a = 7. 834(2), b = 22. 902(6) , c = 10. 147(3)Angstrom, beta = 106. 53(2)degrees, V = 1715(1) Angs trom (3), Z = 2, D-c= 1. 356 g/cm(3) (,) lambda(Mo-k alpha) = 0. 71069 Angs trom; mu = 0. 92cm(-1), F(000) = 752, T = 296K. The final R and R-w values are 0. 065 and 0. 066, respectively. The Cu( I ), Nit ( I ), Co( I ), Zn( I ) complexes with this new ligand have been synthesized and characterized b y elemental analyses, IR, UV, ESI-MS and molar conductance, The macrocyclic ligand molecular structure is centrosymmetrical. All complexes are in acco rdance with the general formula: M(L)(NO3)(2) . nH(2)O (M = Co, Ni, Cu, n = 2; M = Zn, n = 4; L = C36H40-N8O8). The central metal ions coordinate to f our nitrogen atoms of azamacrocycle and two oxygen atoms of one nitrate ion . Preliminary pharmacological tests against P-388 and A-549 tumor cell line s showed that all these complexes had considerable activities in vitro.