P. Dandona et al., Carvedilol inhibits reactive oxygen species generation by leukocytes and oxidative damage to amino acids, CIRCULATION, 101(2), 2000, pp. 122-124
Citations number
13
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Background-The purpose of this study was to test whether carvedilol has an
antioxidant effect in humans in vivo.
Methods and Results-We administered 3.125 mg of carvedilol twice daily to n
ormal subjects for I week. ROS generation by polymorphonuclear leukocytes a
nd mononuclear cells fell from 314+/-183.43 and 303+/-116 mV to 185+/-157 a
nd 189+/-63 mV (P<0.025), respectively. m-Tyrosine fell from 4.24+/-0.99 to
4.03+/-0.97 ng/mL (P=0.01), and o-tyrosine fell from 4.59+/-1.10 to 4.24+/
-0.99 ng/mL (P=0.004) in the absence of a change in phenylalanine concentra
tions.
Conclusions We conclude that carvedilol significantly inhibits ROS generati
on by leukocytes and oxidative conversion of phenylalanine to m- and o-tyro
sine.