Wolf-Hirschhorn syndrome (WHS): a history in pictures

The Wolf-Hirschhorn syndrome (WHS) is a well known chromosomal disorder, du e to a deletion of distal chromosome 4p. The classical gestalt is striking and poses few diagnostic problems, However, due to the difficulty of detect ing very small deletions by standard cytogenetics, diagnosis can be sometim es very difficult, particularly in older patients. In this paper we show th e changes, occurring over time, in facial appearance of affected individual s, to improve insight into the evolution of the phenotype, and to increase its diagnostic potential. Clin Dysmorphol 9:25-30 (C) 2000 Lippincott Willi ams & Wilkins.