Dendritic cells produce interleukin-12 in hyperthyroid mice

Authors
Tamaru, M Matsuura, B Miyauchi, S Onji, M
Citation
M. Tamaru et al., Dendritic cells produce interleukin-12 in hyperthyroid mice, EUR J ENDOC, 141(6), 1999, pp. 625-629
Citations number
25
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
EUROPEAN JOURNAL OF ENDOCRINOLOGY
ISSN journal
08044643 → ACNP
Volume
141
Issue
6
Year of publication
1999
Pages
625 - 629
Database
ISI
SICI code
0804-4643(199912)141:6<625:DCPIIH>2.0.ZU;2-T
Abstract
We previously reported that serum interleukin-12 (IL-12) levels were signif icantly increased in patients with hyperthyroid Graves' disease and in norm al subjects after administration of thyroid hormone. In the present study w e investigated which cells produce IL-12 and the interactions between IL-12 and thyroid hormones, using a hyperthyroid mouse model. Thyroid hormones i nduced IL-12 production, and IL-12 was mainly produced by dendritic cells o utside the thyroid glands in a hyperthyroid state.