ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11

Citation
Ke. Georgiadis et al., ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11, GENOMICS, 62(2), 1999, pp. 312-315
Citations number
14
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENOMICS
ISSN journal
08887543 → ACNP
Volume
62
Issue
2
Year of publication
1999
Pages
312 - 315
Database
ISI
SICI code
0888-7543(199912)62:2<312:AANMOT>2.0.ZU;2-Y
Abstract
A disintegrin-like and metalloprotease domain with thrombospondin type I mo dules (ADAM-TS) describes a novel family of zinc metalloendopeptidases. Its members have a common domain organization, which includes, typically, a pr e-pro-metalloprotease domain, a disintegrin-like domain, and one or more th rombospondin-like (TS) modules. We describe here the complete primary struc ture of mouse;ADAM-TS8, through cloning of Adamts8 cDNA. This novel member of the family contains two TS modules and is highly similar in sequence and domain organization to three other recently described gene products, ADAM- TS5, ADAM-TS6, and ADAM-TS7. Adamts8 is expressed at low levels throughout development and in adult mouse lung and heart. Through analysis of an inter specific backcross panel, we place the Adamts8 locus on mouse chromosome 9 at a consensus position of II cM and its human ortholog, recently reported as the METH2 gene, on human chromosome 11q25, (C) 1999 Academic Press.