Ke. Georgiadis et al., ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11, GENOMICS, 62(2), 1999, pp. 312-315
A disintegrin-like and metalloprotease domain with thrombospondin type I mo
dules (ADAM-TS) describes a novel family of zinc metalloendopeptidases. Its
members have a common domain organization, which includes, typically, a pr
e-pro-metalloprotease domain, a disintegrin-like domain, and one or more th
rombospondin-like (TS) modules. We describe here the complete primary struc
ture of mouse;ADAM-TS8, through cloning of Adamts8 cDNA. This novel member
of the family contains two TS modules and is highly similar in sequence and
domain organization to three other recently described gene products, ADAM-
TS5, ADAM-TS6, and ADAM-TS7. Adamts8 is expressed at low levels throughout
development and in adult mouse lung and heart. Through analysis of an inter
specific backcross panel, we place the Adamts8 locus on mouse chromosome 9
at a consensus position of II cM and its human ortholog, recently reported
as the METH2 gene, on human chromosome 11q25, (C) 1999 Academic Press.