Novel intramolecular radical Ar-C glycosylation-lactonization reaction in the transformation of capuramycin

Authors
Hotoda, H Daigo, M Takatsu, T Muramatsu, A Kaneko, M
Citation
H. Hotoda et al., Novel intramolecular radical Ar-C glycosylation-lactonization reaction in the transformation of capuramycin, HETEROCYCLE, 52(1), 2000, pp. 133-136
Citations number
4
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
52
Issue
1
Year of publication
2000
Pages
133 - 136
Database
ISI
SICI code
0385-5414(20000101)52:1<133:NIRAGR>2.0.ZU;2-X
Abstract
Radical deoxygenation of capuramycin derivative (2a,b) gave the unexpected lactone (3a,b) in moderate yield via a novel intramolecular radical Ar-C gl ycosylation-lactonization reaction. R-115381 and R-116022, thus obtained, s howed weak antimicrobial activity against several Gram-positive bacteria.