Rf. Vieira et al., Synthesis of new 1,2,4-oxadiazoles-derived dipeptidomimetics, a potential class of antiinflammatory drugs, HETEROCYC C, 5(6), 1999, pp. 521-524
Substituted 1,2,4-oxadiazoles containing pseudopeptide moiety as the side c
hain have been synthesized as part of a program of a study aiming to discov
er potential antiinflammatory drugs. A simple and efficient strategy for th
e synthesis started with Boc-protected amino acids (Phe, Asp, Val, Asp, Glu
, Leu and Ile) and reactions conditions to allow the formation of dipeptido
mimetics derivatives in good yields.