Ovarian stimulation and endometrial receptivity

Endometrial receptivity is a limiting step in the success of in-vitro ferti lization (IVF). To investigate this issue, we selected a specific populatio n of high responder patients in whom implantation was impaired, even when g ood quality embryos were transferred, We present a series of studies showin g that high oestradiol concentrations on the day of human chorionic gonadot rophin (HCG) administration are detrimental to uterine receptivity, In addi tion, we suggest clinical strategies to improve endometrial receptivity in high responder patients using a step-down regimen.