NOVEL BIOCATALYTIC REDUCTION OF ARYL AZIDES - CHEMOENZYMATIC SYNTHESIS OF PYRROLO[2,1-C][1,4]BENZODIAZEPINE ANTIBIOTICS

Authors
KAMAL A DAMAYANTHI Y REDDY BSN LAKMINARAYANA B REDDY BSP
Citation
A. Kamal et al., NOVEL BIOCATALYTIC REDUCTION OF ARYL AZIDES - CHEMOENZYMATIC SYNTHESIS OF PYRROLO[2,1-C][1,4]BENZODIAZEPINE ANTIBIOTICS, Chemical communications, (11), 1997, pp. 1015-1016
Citations number
22
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
11
Year of publication
1997
Pages
1015 - 1016
Database
ISI
SICI code
1359-7345(1997):11<1015:NBROAA>2.0.ZU;2-8
Abstract
The chemoselective reduction of aryl azides to aryl amines, and the sy nthesis of the imine-containing pyrrolo[2,1-c]-[1,4]benzodiazepine DNA -binding antitumour antibiotics by selective biocatalytic reductive cy clization of azido aldehydes, has been achieved by employing baker's y east.