Nicotinyl incorporated quinazolinonyl thiadiazoles as possible NSAIDS

Authors
Sarma, GVSR Thomas, J Murugan, V Elango, K
Citation
Gvsr. Sarma et al., Nicotinyl incorporated quinazolinonyl thiadiazoles as possible NSAIDS, I J HET CHE, 9(2), 1999, pp. 151-152
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
09711627 → ACNP
Volume
9
Issue
2
Year of publication
1999
Pages
151 - 152
Database
ISI
SICI code
0971-1627(199910/12)9:2<151:NIQTAP>2.0.ZU;2-6
Abstract
2-[(2,6,8-Trisubstituted-4-(3H)-oxoqunazolin-3-yl) amino]-5-aryl/heteryl-1, 3,4-thiadiazoles (4-12) on reaction with nicotinoyl chloride afforded title compounds viz. 3-{[N-(2,6,8-trisubstituted-4(3H)-oxoquinazolin-3-yl) -N-ni cotinyl] amino}-5-aryl/hereryl-1,3,4-thiadiazoles (13-21) in quantitative y ields. Nine such title compounds were evaluated for antiinflammatory activi ty by standard In-vivo and In-vitro models. They exhibited significant prot ection against carrageenan induced rat paw edema.