Construction of urease-negative mutants of Yersinia enterocolitica serotypes O : 3 and O : 8. Role of urease in virulence and arthritogenicity

Authors
Gripenberg-Lerche, C Zhang, LJ Ahtonen, P Toivanen, P Skurnik, M
Citation
C. Gripenberg-lerche et al., Construction of urease-negative mutants of Yersinia enterocolitica serotypes O : 3 and O : 8. Role of urease in virulence and arthritogenicity, INFEC IMMUN, 68(2), 2000, pp. 942-947
Citations number
29
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
2
Year of publication
2000
Pages
942 - 947
Database
ISI
SICI code
0019-9567(200002)68:2<942:COUMOY>2.0.ZU;2-M
Abstract
Yersinia enterocolitica serotype O:3 and O:8 urease-negative mutants unable to express the 19-kDa beta subunit of urease were constructed and tested f or virulence and arthritogenicity. Our results indicate that urease is need ed for full virulence in oral infections and that it is not an arthritogeni c factor in the rat model.