Candida albicans-derived beta-1,2-linked mannooligosaccharides induce desensitization of macrophages

Authors
Jouault, T Fradin, C Trinel, PA Poulain, D
Citation
T. Jouault et al., Candida albicans-derived beta-1,2-linked mannooligosaccharides induce desensitization of macrophages, INFEC IMMUN, 68(2), 2000, pp. 965-968
Citations number
31
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
2
Year of publication
2000
Pages
965 - 968
Database
ISI
SICI code
0019-9567(200002)68:2<965:CABMID>2.0.ZU;2-W
Abstract
Candida albicans beta-1,2-oligomannosides stimulate macrophage tumor necros is factor alpha (TNF-alpha) but not NO release. This stimulation desensitiz ed macrophages by altering beta-1,2-oligomannoside-dependent TNF-alpha prod uction and lipopolysaccharide-dependent TNF-alpha and NO secretion. Desensi tization was not related to tyrosine phosphorylation signal transduction bu t was transferred by culture supernatants in which arachidonic acid derivat ives were evidenced.