Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans

Authors
Cruz, MC Sia, RAL Olson, M Cox, GM Heitman, J
Citation
Mc. Cruz et al., Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans, INFEC IMMUN, 68(2), 2000, pp. 982-985
Citations number
28
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
2
Year of publication
2000
Pages
982 - 985
Database
ISI
SICI code
0019-9567(200002)68:2<982:COTROC>2.0.ZU;2-P
Abstract
The calcineurin gene was cloned and disrupted in serotype D strains of Cryp tococcus neoformans. Serotype A and serotype D calcineurin mutants were inv iable at 37 degrees C and avirulent in mice, whereas only serotype A mutant s were cation stress sensitive. Thus, calcineurin plays conserved and diver gent roles in serotype A and serotype D strains.