Citation
S. Ghosal et al., 3 '-Deoxyribonucleosides and their derivatives as anti-amoebic agents, INT J PHARM, 194(1), 2000, pp. 15-20
Citations number
18
Categorie Soggetti
Pharmacology & Toxicology
Journal title
INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN journal
03785173
→ ACNP
Volume
194
Issue
1
Year of publication
2000
Pages
15 - 20
Database
ISI
SICI code
0378-5173(20000120)194:1<15:3'ATDA>2.0.ZU;2-I
Abstract
In general nucleoside analogues were found to possess in vitro amoebicidal
property against trophozoites of Entamoeba histolytica. The acid-labile nat
ure of these compounds completely destroyed their ability to cure caecal am
oebiasis of rats. However the therapeutic efficacy of one of these compound
s yielded most promising results, with 10% cures when it was administered a
s enteric coated formulation. (C) 2000 Elsevier Science B.V. All rights res
erved.