Measles history and atopic diseases - A population-based cross-sectional study

Context Many recent cross-sectional studies have suggested that lack of ear ly exposure to communicable diseases, including measles, in affluent countr ies may have increased rates of atopic disease. Objective To study the association between natural measles infection and at opy, Design and Setting Cross-sectional nationwide study in Finland using data g athered between November 1, 1982, and June 30, 1986. Subjects A total of 547 910 individuals aged 14 months to 19 years who at t he time of measles-mumps-rubella (MMR) vaccination had relevant information collected on the occurrence of measles and allergic rhinitis, eczema, and asthma. Main Outcome Measures Lifetime occurrence of atopic manifestations in subje cts who had had measles compared with those who had not, expressed as age-s pecific and age-adjusted prevalence ratios. Results The age-adjusted prevalence ratio of atopic manifestations among th ose who had had measles (n = 20 690) compared with those who had not (n = 5 27 220) was 1.32 (95% confidence interval [CI], 1.27-1.36) for eczema, 1.41 (95% CI, 1.33-1.49) for rhinitis, and 1.67 (95% CI, 1.54-1.79) for asthma. The positive association between measles and atopy was evident at all ages , in both urban and rural dwellers, and among subjects with many or few con tacts at home or in day care. Conclusions Based on our data, measles and atopy occur more frequently toge ther than expected, which does not support the hypothesis that experiencing natural measles infection offers protection against atopic disease.