Molecular basis of spatio-temporal dynamics in Inositol 1,4,5-trisphosphate-mediated Ca2+ signalling

Inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ signalling regulates many important cell functions, and the spatio-temporal dynamics of the Ca2+ sign alling is a crucial factor for its versatility. The molecular mechanisms th at control Ca2+ signalling are now being investigated, and I here describe the subtypes of IP3 receptors that have distinct functional properties and contribute to the diversity of Ca2+ signalling patterns. I also discuss the spatio-temporal dynamics of intracellular IP3 concentration, describing re cent methodological advances in monitoring intracellular IP3 concentration. These findings highlight the potential importance of the spatio-temporal i nformation of any signalling molecule.