Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria

Authors
Takahashi, A Onodera, K Shinoda, H Mayanagi, H
Citation
A. Takahashi et al., Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria, JPN J PHARM, 82(1), 2000, pp. 82-84
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JAPANESE JOURNAL OF PHARMACOLOGY
ISSN journal
00215198 → ACNP
Volume
82
Issue
1
Year of publication
2000
Pages
82 - 84
Database
ISI
SICI code
0021-5198(200001)82:1<82:PAIM5S>2.0.ZU;2-X
Abstract
The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-ph enylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were ex amined in vitro. Both phenytoin and HPPH induced significant bone resorptio n as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.