Comprehensive review of the psychiatric uses of valproate

The therapeutic effects of valproate in psychiatric conditions are most sub stantially recognized in bipolar disorder. However, this well-tolerated med ication may be beneficial in the treatment of other mental illnesses. In th is article, the authors comprehensively review studies of valproate as trea tment for psychiatric conditions, including bipolar, depressive, anxiety, a nd psychotic disorders; alcohol withdrawal and dependence; tardive dyskines ia; agitation associated with dementia; and borderline personality disorder . Valproate shows the most promising efficacy in treating mood and anxiety disorders, with possible efficacy in the treatment of agitation and impulsi ve aggression, and less convincing therapeutic response in treating psychos is and alcohol withdrawal or dependence. The authors conclude with a brief summary of its mechanism of action and therapeutic spectrum.