Parallel synthesis of alkyl tetrazole derivatives using solid support chemistry

Authors
Matthews, DP Green, JE Shuker, AJ
Citation
Dp. Matthews et al., Parallel synthesis of alkyl tetrazole derivatives using solid support chemistry, J COMB CHEM, 2(1), 2000, pp. 19-23
Citations number
13
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
JOURNAL OF COMBINATORIAL CHEMISTRY
ISSN journal
15204766 → ACNP
Volume
2
Issue
1
Year of publication
2000
Pages
19 - 23
Database
ISI
SICI code
1520-4766(200001/02)2:1<19:PSOATD>2.0.ZU;2-W
Abstract
The synthesis of several omega-chloroalkyl tetrazoles and their subsequent attachment to a solid support is described. Using an in situ Finkelstein re action, a variety of nucleophiles were alkylated and then cleaved from the resin to give pure alkyl tetrazole derivatives. A sample library of 5 x 6 d emonstrates the general utility of this sequence.