Kk. Sadasivan et al., NEUTROPHIL-MEDIATED MICROVASCULAR INJURY IN ACUTE, EXPERIMENTAL COMPARTMENT SYNDROME, Clinical orthopaedics and related research, (339), 1997, pp. 206-215
The purpose of this study was to determine the contribution of neutrop
hils and tissue xanthine oxidase to the skeletal muscle microvascular
dysfunction in an ex vivo model of acute compartment syndrome. Adult d
ogs were rendered neutropenic or depleted of tissue xanthine oxidase b
efore gracilis muscle isolation, Compared with continuously perfused,
nonischemic muscles, acute, experimental compartment syndrome resulted
in a dramatic increase in microvascular permeability, muscle neutroph
il content, and muscle vascular resistance, Neutropenia prevented, whe
reas xanthine oxidase depletion had no effect on, the microvascular dy
sfunction and muscle neutrophil infiltration elicited by experimental
compartment syndrome, These results suggest that neutrophils contribut
e to the microvascular dysfunction and blood flow distribution abnorma
lities elicited by acute, experimental compartment syndrome.