The stability of self-inclusion complexes of cyclodextrin derivatives bearing a p-dimethylaminobenze moiety

An appending moiety of modified cyclodextrins acts as an intramolecular gue st and forms a self-inclusion complex in aqueous solution. In this study, t he stability of self-inclusion complexes of modified cyclodextrins which ha ve a p-dimethylaminobenzene moiety was analyzed by fluorescent decay analys es, and the factor that determines the stability of the self-inclusion comp lex was determined by a computational approach. The self-inclusion form is stabilized mainly due to van der Waals interaction between the appending mo iety and the cyclodextrin ring.