Synthesis of [C-14]-labelled glycidyl and glycerol ethers of aliphatic andaromatic alcohols.

The synthesis of [C-14]-labelled glycidyl ethers and the corresponding glyc erol ethers is described for the monofunctional compounds 1-dodecanol and o rtho-cresol and the bifunctional compounds 4,4'-dihydroxy-3,3',5,5'-tetrame thyl biphenyl and 1,6-hexanediol. The synthesis is based on reaction betwee n the alcohol and [U-C-14]-epichlorohydrin (1). The aromatic compounds have been converted to the corresponding glycidyl ethers by using sodium hydrox ide and the aliphatic compounds by using tin(IV) chloride as a catalyst. Th us radio-labelled glycidyl ethers were obtained in yields between 50-80%, w ith a chemical purity of > 92% and a radiochemical purity of > 95% by HPLC. The specific activities of the glycidyl ethers were approximately 0.2 mCi/ mmol for the monofunctional compounds and approximately 0.4 mCi/mmol for th e bifunctional compounds.