Synthesis of C-13,H-2(3)-salmeterol: An analytical internal standard for pharmacokinetic studies

Authors
Goodwin, TE Zhou, X Haile, PA Breen, P Anderson, PJ Hiller, FC Compadre, CM
Citation
Te. Goodwin et al., Synthesis of C-13,H-2(3)-salmeterol: An analytical internal standard for pharmacokinetic studies, J LABEL C R, 43(1), 2000, pp. 65-75
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
43
Issue
1
Year of publication
2000
Pages
65 - 75
Database
ISI
SICI code
0362-4803(200001)43:1<65:SOCAAI>2.0.ZU;2-A
Abstract
A convenient synthesis of an isotopically-labelled version (C-13,H-2(3)) of the long-acting beta(2)-adrenergic agonist, salmeterol, is described, star ting from methyl salicylate, 1,6-dibromohexane and 4-phenyl-1-butanol. This compound was designed as an analytical internal standard for mass spectrom etric determination of salmeterol in pharmacokinetic studies.