This report deals with two stereochemically different tridentate N-3-ligand
s suitable as ancillary ligands in the organometallic chemistry of rutheniu
m. [{Ru(p-cymene)(Cl)}(2)(mu-Cl)(2)] assisted the template synthesis of a t
ridentate N-3-macrocycle derived from 2-aminobenzaldehyde, thus forming [Ru
(eta(3)-C21H15N3)Ru(p-cymene)](2+) 2Cl(-), 1. The ligand 2, Pyr-Pic.H, deri
ved from the condensation of pyrrole-2-aldehyde and 2-picolylamine, functio
ns as a monoanionic tridentate ligand in the reaction with [{Ru(COD)(Cl)}(2
)(mu-Cl)(2)] leading to [Ru(COD)(Cl)(Pyr-Pic-H-2)], 4, which undergoes the
ionization of the Ru-Cl bond both in pyridine or in THF in the presence of
AgTf, leading to [Ru(Pyr-Pic-H)Py-3](+) Cl-, 5 and [Ru(COD)(Pyr-Pic-H)Tf],
6, respectively. The alkylation of 4 using LiMe led to [(Ru-Me)(Pyr-Pic-H)(
COD)], 7, which undergoes a methane elimination to yield [Ru-2(mu-Pyr-Pic)(
2)(COD)(2)], 8. The reaction of potassium-pyren [pyren = N,N'-ethylenebis(2
-pyrrolyliminato)dianion], 10, with [{Ru(COD)(Cl)}(2)(mu-Cl)(2)] led to the
Ru-macrocyclic derivative [Ru(Pyren)(COD)], 11, where COD fills two cis-po
sitions around ruthenium. Extended Huckel calculations have been carried ou
t on the two stereochemically different Ru-N-3 fragments having a facial (s
ee complex 1) and a meridional (4, 5, 6, 7 and 8) arrangements in order to
identify the difference in the frontier orbitals for the metal reactivity.
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