Citation
R. Aldea et H. Alper, Ruthenium clay catalyzed reduction of alpha-iminoesters and alpha-iminoketones, and the reductive amination of alpha-ketoesters, J ORGMET CH, 594, 2000, pp. 454-457
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANOMETALLIC CHEMISTRY
ISSN journal
0022328X
→ ACNP
Volume
594
Year of publication
2000
Pages
454 - 457
Database
ISI
SICI code
0022-328X(20000115)594:<454:RCCROA>2.0.ZU;2-U
Abstract
The reduction of alpha-iminoesters and alpha-iminoketones to the correspond
ing amino compounds was accomplished using ruthenium clay as the catalyst,
at 75-100 degrees C and 600-900 psi H-2. The same catalyst proved efficient
for the reductive amination of alpha-ketoesters (100 degrees C, 600 psi H-
2). Diastereomeric excesses of up to 78% were obtained in the reductive ami
nation reaction. (C) 2000 Elsevier Science S.A. All rights reserved.