I. Bergada et al., Serum inhibin B concentration in a prepubertal boy with gynecomastia and Peutz-Jeghers syndrome, J PED END M, 13(1), 2000, pp. 101-103
Gynecomastia in boys with Peutz-Jeghers syndrome and Sertoli cell tumors of
gonadal origin results from increased estrogen production due to increased
aromatase activity within the testicular tumor. We present a prepubertal b
oy with Peutz-Jeghers syndrome, gynecomastia and bilateral neoplastic Serto
li cell proliferation in whom the only abnormal hormonal profile was increa
sed concentration of inhibin B and Pro-alpha C in serum.