The effect of CP-96,345, a non-peptide substance-P antagonist, on thermoregulation and the development of endotoxin-fever in rats

Authors
Balasko, M Szekely, M Szelenyi, Z
Citation
M. Balasko et al., The effect of CP-96,345, a non-peptide substance-P antagonist, on thermoregulation and the development of endotoxin-fever in rats, J THERM BIO, 25(1-2), 2000, pp. 1-4
Citations number
13
Categorie Soggetti
Animal Sciences",Physiology
Journal title
JOURNAL OF THERMAL BIOLOGY
ISSN journal
03064565 → ACNP
Volume
25
Issue
1-2
Year of publication
2000
Part
2
Pages
1 - 4
Database
ISI
SICI code
0306-4565(200002/04)25:1-2<1:TEOCAN>2.0.ZU;2-#
Abstract
1. Substance-P (SP) has been shown to induce a regulated rise in body tempe rature when injected into one of the lateral cerebral ventricles of rats. 2. The non-peptide antagonist of SP (CP-96,345) decreased the SP-induced ri se in core temperature and, when given prior to an intravenous endotoxin in jection, it also attenuated the febrile response to endotoxin. (C) 2000 Els evier Science Ltd. All rights reserved.