Effect of perinatal NaCl exposure on the angiotensin-induced temperature response in adult SD rats

Rats were exposed perinatally (diets were starred in darns before gestation and were maintained through postnatal day 28) to either basal (0.12%), mid (1%), high (3%) or very high (6%) NaCl diets. They were then placed on reg ular Purina diets. Temperature responses to angiotensin II and isoprotereno l were assessed in adulthood in the male offspring. Temperature responses i nduced by angiotensin II, but not isoproterenol were significantly greater in rats exposed to the basal (0.12%) compared to the high (3-6%) NaCl diets during the perinatal period. This difference may reflect changes that occu r in Ang II receptors or responsiveness during the developmental period. (C ) 2000 Elsevier Science Ltd. All rights reserved.