A new antioxidant compound H-290/51 attenuates heat shock protein (HSP 72 kD) response, edema and cell injury following acute heat exposure. An experimental study using light and electron microscopy in the rat

Rats exposed to 4 h heat stress at 38 degrees C exhibited upregulation of h eat shock protein (HSP 72 kD) expression in several brain regions associate d with brain edema and cell injury. Pretreatment with a new anti-oxidant co mpound H-290/51 (50 mg/kg, per os, 30 min before stress) significantly atte nuated HSP expression brain edema and cell injury. These results suggest th at oxidative stress associated with brain edema plays important roles in HS P expression, not reported earlier. (C) 2000 Elsevier Science Ltd. All righ ts reserved.