S. Westaby et al., Is there a relationship between serum S-100 beta protein and neuropsychologic dysfunction after cardiopulmonary bypass?, J THOR SURG, 119(1), 2000, pp. 132-137
Citations number
29
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Objectives: Over the past decade, the glial protein S-100 beta has been use
d to detect cerebral injury in a number of clinical settings including card
iac surgery. Previous investigations suggest that S-100 beta is capable of
identifying patients with cerebral dysfunction after cardiopulmonary bypass
. Whether detection of elevated levels S-100 beta reflects long-term cognit
ive impairment remains to be shown. The present study evaluated whether per
ioperative release of S-100 beta after coronary artery operations with card
iopulmonary bypass could predict early or late neuropsychologic impairment.
Methods: A total of 100 patients undergoing elective coronary bypass witho
ut a previous history of neurologic events were prospectively studied. To e
xclude noncerebral sources of S-100 beta, we did not use cardiotomy suction
or retransfusion of shed mediastinal blood. Serial perioperative measureme
nts of S-100 beta were performed with the use of a new sensitive immunolumi
nometric assay up to 8 hours after the operation. Patients underwent cognit
ive testing on a battery of 11 tests before the operation, before discharge
from the hospital, and 3 months later. Results: No significant correlation
was found between S-100 beta release and neuropsychologic measures either
5 days or 3 months after the operation, Conclusion: Despite using a sensiti
ve immunoluminometric assay of S-100 beta, we found no evidence to support
the suggestion that early release of S-100 beta may reflect long-term neuro
logic injury capable of producing cognitive impairment.