Sj. Foley et al., A prospective study of the natural history of hematuria associated with benign prostatic hyperplasia and the effect of finasteride, J UROL, 163(2), 2000, pp. 496-498
Purpose: We prospectively studied the effect of finasteride on chronic hema
turia associated with benign prostatic hyperplasia.
Materials and Methods: We prospectively evaluated 57 patients with chronic
intermittent hematuria who were randomized to a finasteride treated or a co
ntrol arm.
Results: In the untreated control group hematuria recurred in 17 patients (
63%) within a year but in only 4 (14%) in the finasteride group, which was
a statistically significant difference (p < 0.05). Surgery was required for
bleeding in 7 controls (26%), while no patient on finasteride required sur
gery.
Conclusions: Hematuria secondary to prostatic bleeding may be significant i
f not treated. Finasteride appears to be effective for suppressing hematuri
a caused by benign prostatic hyperplasia and should be considered as treatm
ent.