L. Givalois et al., Concomitant changes in CRH mRNA levels in rat hippocampus and hypothalamusfollowing immobilization stress, MOL BRAIN R, 75(1), 2000, pp. 166-171
By using in situ hybridization, we have demonstrated an increased expressio
n of corticotropin-releasing hormone (CRH) mRNA in the hippocampus followin
g immobilization stress (3 h) in rats. It paralleled that measured in the h
ypothalamic paraventricular nucleus (PVN). Pretreatment of control and stre
ssed rats with MK-801 (a NMDA receptor antagonist) further increased CRH mR
NA expression, in the two structures. The concomitant up-regulation of CRH
mRNA expression in these structures suggests a common regulatory finality f
or a single molecule at two different loci. (C) 2000 Elsevier Science B.V.
All rights reserved.