HYPONATREMIA AND NEUROLEPTIC-INDUCED OBESITY IN RATS

Authors
SILVA E CATALAN M HERNANDEZ L TENEUD L BAPTISTA T
Citation
E. Silva et al., HYPONATREMIA AND NEUROLEPTIC-INDUCED OBESITY IN RATS, Research communications in molecular pathology and pharmacology, 85(2), 1994, pp. 237-240
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy",Pathology
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
85
Issue
2
Year of publication
1994
Pages
237 - 240
Database
ISI
SICI code
1078-0297(1994)85:2<237:HANOIR>2.0.ZU;2-S
Abstract
The weight gain and hyperphagia induced by chronic administration of s ulpiride in female rats were not prevented by the concomitant administ ration of an extra source of sodium. In addition, serum sodium levels were not affected, but potassium levels were significantly reduced by sulpiride administered for 1 week. These results suggest that sulpirid e-induced obesity in rats is not related to sodium imbalance. The mech anism for the decrease in serum potassium levels and its relation with sulpiride-induced weight gain warrant further investigation.